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All the files associated with the peer-reviewed, accepted manuscript must be submitted. Therefore, the NIHMS system supports a wide variety of file types (MS Word, WordPerfect, PDF, PowerPoint, Excel, etc.). As required by journals, high-resolution images (i.e., .pdf, .tiff, .jpg, .eps, .ai) should be submitted to ensure the best reproduction quality in PubMed Central (PMC). With the exception of supplementary material, PMC will convert submitted images into standard file types.