The National Library of Medicine (NLM) responded swiftly and nimbly to the COVID-19 pandemic. It has built innovative services for rapid acquisition, access, and use of COVID-19/Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) information. Although federal COVID-19 Public Health Emergency ended in May 2023, NLM continues to provide resources for exploration of literature, clinical, genetic, and molecular information relating to COVID-19 and SARS-CoV-2.
NLM resources relating to COVID-19/SARS-CoV-2 include:
- LitCovid: Access current COVID-19/SARS-CoV-2 literature.
- PubMed®: Search for citations on COVID-19 and SARS-CoV-2 articles within a large body of biomedical and life-science journals.
- PubMed Central®: A free full-text archive of biomedical and life sciences journal literature:
- National Center for Biotechnology Information (NCBI) Bookshelf: Access free online books and documents, including those on COVID-19.
- MedlinePlus (also in Spanish): Find consumer health information, including on COVID-19.
- ClinicalTrials.gov: Access information about clinical studies on COVID-19 taking place around the world.
- PubMed® Clinical Queries: Find clinically relevant COVID-19 articles in PubMed through specialized clinical topic searching.
- dbGaP: Find studies that focus on COVID-19 within studies of human genotypes/phenotypes.
- Genetic Testing Registry (GTR®): See the COVID-19 tests that labs registered with this service.
- NCBI Gene: Access human gene records that contain COVID-19 related annotation within a large collection of integrated information on genes from numerous organisms.
Resources for Accessing and Analyzing SARS-CoV-2 Sequences and Other Molecular Data
- SARS-CoV-2 reference genome (NC_045512):
- View the NC_045512 record.
- Visualize the genome with annotated genes.
- Display records for the annotated genes in the Gene database.
- Download the genome annotation.
- The NCBI Virus portal for viral sequence data from RefSeq, GenBank and other NCBI repositories:
- Search, retrieve, and analyze sequences and other content in the SARS-CoV-2 Data Hub Interactive Dashboard.
- Delve deeper into geotemporal and mutation data on variants and lineages via interactive SARS-CoV-2 Variants Overview dashboard.
- Get the latest list of SARS-CoV-2 nucleotide sequences. You can query these IDs in GenBank.
- NCBI Datasets: Find, browse, and download SARS-CoV-2 genome and protein sequences, annotation, and a data report in this new NCBI service for genomic data.
- NCBI Sequence Read Archive (SRA) containing high throughput sequencing data from all branches of life:
- BLAST®: Search Betacoronavirus nucleotide sequences database as one of many specialized databases and programs for finding regions of similarity between biological sequences.
- Structure: Explore SARS-CoV-2 protein structures, domains, and sequences within a wealth of information on protein domains and macromolecular structures.
- PubChem: Select from a compiled list of COVID-19/SARS-CoV-2 related records within myriads of compounds, substances, pathways, and bioassays contributed by hundreds of data sources.
- GEO: Search for COVID-19/SARS-CoV-2 studies within a repository of gene expression and other experimental studies.